1-9 A-D E-G H-M N-P Q-S T-Z

PHENOXY ETHANOL(FENOKSIETANOL)

PHENOXY ETHANOL(FENOKSIETANOL); CAS NUMBER: 122-99-6; 2-phenoxyethanol;Emuclens;Erisept;ethylene glycol monophenyl ether;phenoxethol;phenoxyethanol;2-PHENOXYETHANOL;122-99-6;Phenoxyethanol;Ethylene glycol monophenyl ether;Phenyl cellosolve;Phenoxytol;Ethanol, 2-phenoxy-;Phenoxethol;Phenoxyethyl alcohol;Phenoxetol;Arosol;Rose ether;Ethylene glycol phenyl ether;Phenylmonoglycol ether;2-Phenoxyethan-1-Ol;1-Hydroxy-2-phenoxyethane;Dowanol EP;2-Phenoxyethyl alcohol;Glycol monophenyl ether;Fenyl-cellosolve;2-Fenoxyethanol;2-Hydroxyethyl phenyl ether;Dowanol EPH;beta-Hydroxyethyl phenyl ether;Emery 6705;Emeressence 1160;Fenylcelosolv;Phenylglycol;Marlophen P;Marlophen P 7;2-Phenoxy-ethanol;Spermicide 741;Tritonyl 45;Ethylan HB 4;EGMPE;Fenylcelosolv [Czech];Phenooxy alcohol;2-Fenoxyethanol [Czech];Fenyl-cellosolve [Czech];Plastiazan-41 [Russian];UNII-HIE492ZZ3T;NSC 1864;Polyoxyethylene phenol ether;Polyoxyethylene phenyl ether;beta-Phenoxyethanol;Phenol-ethylene oxide adduct;Glycols, polyethylene, monophenyl ether;Phenoxyethanol [NF];Polyethylene glycol phenyl ether;.beta.-Hydroxyethyl phenyl ether;HSDB 5595;Phenyl monoglycol ether;PHE-G;PHE-S;Rose ether phenoxyethanol;EINECS 204-589-7;FR 214;.beta.-Phenoxyethyl alcohol;alpha-Phenyl-omega-hydroxypoly(oxy-1,2-ethanediyl);BRN 1364011;AI3-00752()C;9004-78-8;CHEBI:64275;C8H10O2;QCDWFXQBSFUVSP-UHFFFAOYSA-N;Poly(oxy-1,2-ethanediyl), ?-phenyl-?-hydroxy-;MFCD00002857;Phenoxyethanol (NF);Poly(oxy-1,2-ethanediyl), alpha-phenyl-omega-hydroxy-;NCGC00090731-01;NCGC00090731-05;DSSTox_CID_1976;DSSTox_RID_76437;DSSTox_GSID_21976;2-Phenoxyethanol-1,1-d2;Erisept;Plastiazan-41;56257-90-0;AS-122-99-6;Phenol, ethoxylated;.beta.-Phenoxyethanol;monophenylglycol;Phenoxyethanolum;Phenoxytolarosol;CCRIS 9481;Phenoxyl ethanol;arosol[qr];2-phenyloxyethanol;2-phenoxy ethanol;2-(phenoxy)ethanol;Dowanol EP / EPH;beta-phenoxyethylalcohol;ACMC-1BVYG;(2-Hydroxyethoxy)benzene;2-Phenoxyethanol, 99%;2-phenoxyethylalcohol[qr];beta-hydroxyethylphenylether;WLN: Q2OR;phenol, ethoxyliert (6eo);polyethyleneglycolphenylether;AC1L1L7D;AC1Q7D8M;HIE492ZZ3T;SCHEMBL15708;2-Phenoxyethanol, >=99%;4-06-00-00571 (Beilstein Handbook Reference);KSC174Q0P;MLS002174254;ethyleneglycol monophenyl ether;Euxyl K 400 (Salt/Mix);beta-hydroxyethylphenylether[qr];phenol, ethoxyliert, eo 4 mol;Jsp001544;CHEMBL1229846;DTXSID9021976;CTK0H4807;phenol, ethoxyliert, eo 30 mol;Ethylene glycol mono phenyl ether;NSC1864;MolPort-001-768-719;BB_SC-2741;HMS2268A20;Poly(oxy-1,2-ethanediyl), .alpha.-phenyl-.omega.-hydroxy-;NSC-1864;STR04582;ZINC1577061;Tox21_111002;Tox21_113532;Tox21_202111;Tox21_300842;ANW-18088;BBL027410;LS-672;SBB060485;STK802556;ZINC01577061;2-Phenoxyethanol, analytical standard;Fungal Terminator [veterinary] (TN);AKOS000118741;Tox21_111002_1;MCULE-1828011376;RP20453;RTR-003651;TRA0162661;NCGC00090731-02;NCGC00090731-03;NCGC00090731-04;NCGC00090731-06;NCGC00090731-07;NCGC00090731-08;NCGC00254745-01;NCGC00259660-01;AJ-27363;AK110792;AN-19469;AN-22895;BC208517;CJ-05434;CJ-24993;Ethylene glycol monophenyl ether, >=90%;KB-25856;LP119824;LS-72941;OR034465;OR190422;SC-47140;SMR000112131;ETHANOL,2-PHENOXY MFC8 H10 O2;ST2417151;TR-003651;FT-0613280;P0115;P1953;ST51046662;2-phenoxyethanol(ethyleneglycolmonophenylether);2-Phenoxyethanol, tested according to Ph.Eur.;D08359;97692-EP2287158A1;97692-EP2305662A1;97692-EP2372017A1;A805003;SR-01000838345;I01-8824;J-510235;SR-01000838345-2;F1905-6997;Z426194440;Ethylene glycol monophenyl ether, SAJ first grade, >=95.0%;Phenoxyethanol, European Pharmacopoeia (EP) Reference Standard;Phenoxyethanol, United States Pharmacopeia (USP) Reference Standard;InChI=1/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H;2-Phenoxyethanol, pharmaceutical secondary standard; traceable to USP and PhEur;1020398-73-5;134367-25-2;18249-17-7;200260-63-5;37220-49-8;37813-33-5;79586-53-1;FENOKSİETHANOL;FENOKSIETHANOL;FENOKSI ETHANOL;FENOKSİ ETHANOL;PHENOXY ETHANOL;PHENOXY ETANOL;FENOKSİ ETANOL;FENOKSI ETANOL;fenoksi ethanol;fenoksı ethanol;phenoxy ethanol;phenoxy etanol;fenoksiethanol;phenoxyethanol;phenoxyetanol;fenoksıethanol;Fenoksi Ethanol;Phenoxy Ethanol;Fenoksi Etanol;Phenoxy Etanol;FenoksiEthanol;PhenoxyEthanol;FenoksiEtanol;PhenoxyEtanol;fenoksiethanol;2-PHENOXYETHANOL;2-Phenoxyethyl alcohol;3-ETHYL-2-HEPTANOL;DOWANOL(TM) EPH;ETHYLENE GLYCOL MONOPHENYL ETHER;ETHYLENE GLYCOL PHENYL ETHER;MONOPHENYL GLYCOL;PHENOXETOL;PHENOXYETHANOL;PHENOXYETHANOLUM;PHENYL CELLOSOLVE;PHENYLGLYCOL;ROSE ETHER;1-Hydroxy-2-phenoxyethane;1-hydroxy-2-phenoxyethane[qr];2-Fenoxyethanol;2-fenoxyethanol(czech)[qr];2-Hydroxyethyl phenyl ether;2-Hydroxyethylphenylether;2-hydroxyethylphenylether[qr];fenoksiethanolveuygulamalanları;fenoksiethanolvekozmetik;fenoksi ethanol ve uygulamaları;fenoksi ethanol ve kozmetik;phonexyethanolandapplication;phenoxyethanolandcosmetics;phenoxy ethanol and application;phenoxy ethanol and cosmetics;PHENOXY ETHANOL AND APPLICATION; PHENOXY ETHANOL AND COSMETICS


EC SAYISI: 204-589-7

Fenoksi Etanolün Moleküler Formülü
C8H10O2

C6H5OC2H4OH
Fenoksi Etanolün Kimyasal ve Fiziksel Özellikleri

Özellik adı
Moleküler Ağırlık: 138.166 g / mol
Hidrojen Bağımı Bağışlayıcı Sayısı: 1
Hidrojen Bağ Alıcı Sayısı: 2
Dönebilen Bond Sayısı: 3
Karmaşıklık: 77.3
Topolojik Polar Yüzey Alanı: 29.5 A ^ 2
Monoizotopic Kütle: 138.068 g / mol
Tam Kütle: 138.068 g / mol
XLogP3: 1.2
Bileşik Canonicalized: true
Resmi Şarj: 0
Ağır Atom Sayısı: 10
Tanımlı Atom Stereocenter Sayısı: 0
Tanımsız Atom Stereocenter Sayısı: 0
Tanımlı Bono Stereocenter Sayısı: 0
Tanımlanmamış Bond Stereocenter Sayısı: 0
İzotop Atom Sayısı: 0
Kovalent Bağlı Birim Sayısı: 1

Fenoksi Etanolün Deneysel Özellikleri

Fenoksi Etanolün Fiziksel Tanımı

Etilen glikol fenil eter hoş bir kokuya sahip renksiz bir sıvıdır. Yoğunluk 1.02 g / cm3. Bir tahriş edici.

Fenoksi Etanolun Rengi
Yağlı sıvı

Fenoksi Etanol Kokusu
Kötü aromatik koku

Fenoksi Etanol Tadı
Yanan tadı

Fenoksi Etanol Kaynama Noktası
760 mm Hg'de 473.4 ° F

Fenoksi Etanol Erime Noktası
57 ° F

Fenoksi Etanol Yoğunluğu
1,104

Fenoksi Etanolün Genel Tanıtımı ve Uygulamaları

Glikol eterleri, bir molekül içinde eter, alkol ve hidrokarbon zincirinin kombinasyonuyla hem kutupsal hem de polar olmayan özelliklere sahip çok yönlü ödeme gücü özellikleri sağlar. Uzun hidrokarbon zincirinin kimyasal yapısı, suda çözünürlüğe karşı direnirken, eter veya alkol grupları yükseltilmiş hidrofil çözünürlük performansını getirir. Bu sürfaktan benzeri yapı, su ve bir dizi organik çözücü arasında uyumluluğu ve farklı fazları birleştirmeyi sağlar. Glikol eterleri geniş hidrofilik / hidrofobik dengeleriyle karakterizedir. Glikol eterleri, boya ve fırın kaplamaları imalatında seyrelticiler ve dengeleyici ajanlar olarak kullanılırlar. Glikol eter serisi, nitroselüloz ve kombinasyon vernikleri üretiminde kullanılır. Fren sıvısında katkı maddesi olarak kullanılırlar. Boyanan tekstil ve deri için, böcek öldürücü ve herbisitler için formüle edilmiştir. Yağlı su dispersiyonlu temizleyici ürünlerinde performans sağlarlar. Yavaş buharlaşma oranı nedeniyle baskı endüstrilerinde kullanılırlar. Parfümler, mikrop öldürücü ilaçlar, bakterisitler, böcek kovucuları ve antiseptik için bir fiksatif madde olarak kullanılırlar. Buz birikimini önlemek için jet yakıtı için katkı maddesi olarak kullanılırlar. Glymes, dimetil eterler, kararlılık ve yüksek ödeme gücü sağlayan iki terminal metil grubuna sahiptir. Çözündürücüler ve faz transfer katalizörleri olarak faydalıdırlar. Glymes, düşük kimyasal tepkimelerinden dolayı inert bir reaksiyon orta kimyasal reaksiyon olarak gerekli mülkiyet sunar. Özellikle organometalik ve polimerizasyon reaksiyonları için uygundurlar. Hidroksil grubu içeren glikol eterleri de yararlı kimyasal ara ürünlerdir. Hidroksil grubu, polieter alkoller üretmek üzere epoksi ile hemiasetaller (veya asetaller) üretmek üzere aldehitler (veya ketonlar) ile reaksiyona girerek bir dizi ester üretmek üzere karboksilik asit bileşikleri veya inorganik asitler ile alkoksi alkil halojenürler üretmek üzere halojenleme ajanları ile reaksiyona girer.

Fenoksietanol, deterjanlar, kozmetik ürünleri, tuvalet malzemeleri ve ilaçları içeren kişisel bakım ürünlerinde en yaygın kullanılan koruyucu maddelerden biridir. Bu, gram negatif veya gram pozitif bakterilere, mayalara ve kalıplara karşı geniş bir yelpazede anti-mikrobik etkinlik sağlar. Birçok kutupsuz terkip maddesinde çözünür ve ödeme gücü faaliyete katkıda bulunur. Etkinliği protein bazlı ürünler için de etkilidir. Çoğu ülkede, maksimum% 1 konsantrasyona izin verilir.

 

 

 

 

 

 

 

 

 


EC NUMBER: 204-589-7

Molecular Formula of Phenoxy Ethanol
C8H10O2

C6H5OC2H4OH
Chemical and Physical Properties of Phenoxy Ethanol

Property Name
Molecular Weight: 138.166 g/mol
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 3
Complexity: 77.3
Topological Polar Surface Area: 29.5 A^2
Monoisotopic Mass: 138.068 g/mol
Exact Mass: 138.068 g/mol
XLogP3: 1.2
Compound Is Canonicalized: true
Formal Charge: 0
Heavy Atom Count: 10
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Isotope Atom Count: 0
Covalently-Bonded Unit Count: 1

Experimental Properties of Phenoxy Ethanol

Physical Description of Phenoxy Ethanol

Ethylene glycol phenyl ether is a colorless liquid with a pleasant odor. Density 1.02 g / cm3. An irritant.

Color of Phenoxy Ethanol
Oily liquid

Odor of Phenoxy Ethanol
Faint aromatic odor

Taste of Phenoxy Ethanol
Burning taste

Boiling Point of Phenoxy Ethanol
473.4° F at 760 mm Hg

Melting Point of Phenoxy Ethanol
57° F

Density of Phenoxy Ethanol
1.104

GENERAL DESCRIPTION & APPLICATIONS of Phenoxy Ethanol

Glycol ethers, with the combination of ether, alcohol and hydrocarbon chain in one molecule, provide versatile solvency characteristics with both polar and non-polar properties. The chemical structure of long hydrocarbon chain resist to solubility in water, while ether or alcohol groups introduce the promoted hydrophilic solubility performance. This surfactant-like structure provides the compatibility between water and a number of organic solvents, and the ability to couple unlike phases. Glycol ethers are characterized by their wide range of hydrophilic/hydrophobic balances. glycol ethers are used as diluents and levelling agents in the manufacture of paints and baking finishes. Glycol ether series are used in the manufacture of nitrocellulose and combination lacquers. They are used as an additive in brake fluid. They are formulated for dying textiles and leathers and for insecticides and herbicides. They provides performance in cleaners products with oil-water dispersions. They are used in printing industries as they have a slow evaporation rate. They are used as a fixative for perfumes, germicides, bactericides, insect repellents and antiseptic. They are used as an additive for jet fuel to prevent ice buildup. Glymes, dimethyl ethers, have two terminal methyl groups which offer stability and high solvency. They are useful as solubilizers and phase transfer catalysts. Glymes offer the property required as an inert reaction medium chemical reaction due to their low chemical reactivity. They are suitable particularly for organometallic and polymerization reactions. Glycol ethers which contain hydroxyl group are also useful chemical intermediate. The hydroxyl group will undergo reaction with aldehydes (or ketones) to produce hemiacetals (or acetals), with epoxides to produce polyether alcohols, with halogenating agents to produce alkoxy alkyl halides, with carboxylic acid compounds or inorganic acids to produce a number of esters.

Phenoxyethanol is one of the most widely used preservatives in personal care products including detergents, cosmetics, toiletries and pharmaceuticals. It provides a broad spectrum anti-microbial activity against either gram-negative or gram-positive bacteria, yeasts and moulds. It is soluble in many non-polar ingredients and contributes solvency activity. Its activity is effective in protein-based products also. In most countries, it is permitted to a maximum of 1% concentration.

 CAS Numarası: 122-99-6; IUPAC adı: 2-Fenoksietanol;fenoksi etanol;fenoksietanol;fenoksiethanol;fenoksi ethanol; Phenoxyethanol; Etilen glikol monofenil eter; Phenoxytolarosol; Dowanol EP / EPH; Protectol PE; Emery 6705; Gül eteri; 1-Hidroksi-2-fenoksietan; β-hidroksietil fenil eter; Fenil selosolve; Etilen glikol fenil eter; 2-PHENOXYETHANOL; Cas No: 122-99-6; Phenoxyethanol; Etilen glikol monofenil eter; Etanol, 2-fenoksi-; Phenyl cellosolve; Phenoxytol; Phenoxethol; Phenoxetol; Etilen glikol fenil eter; Fenoksietil alkol; 2-Fenoksietan-1-Ol; 1-Hidroksi-2-fenoksietan; Gül eteri; Fenilmonoglikol eter; Arosol; Dowanol EP; 2-Fenoksietil alkol; Glikol monofenil eter; 2-Hidroksietil fenil eter; Fenilglikol

Fenyl-cellosolve; 2-Fenoksietanol; Dowanol EPH; 2-Fenoksi-etanol; Emery 6705; Emeressence 1160; Fenylcelosolv; Marlophen P; beta-Hidroksietil fenil eter; 2-fenoksi etanol, 2-fenoksietanol; Emuclens; Erisept; etilen glikol monofenil eter; fenoxethol; fenoksietanol

 

Fenil selosolve veya fenoksitol olarak da bilinen 2-Fenoksietanol, fenol eterler olarak bilinen organik bileşikler sınıfına aittir. Bunlar, bir benzen halkası ile ikame edilmiş bir eter grubu içeren aromatik bileşiklerdir. 2-Fenoksietanol katı, çözünür (suda) ve son derece zayıf asidik (esasen nötr) bir bileşik (pKa'sına bağlı olarak) olarak bulunur. 2-Fenoksietanol, dışkı ve tükürük gibi birden fazla biyoyakıtta tespit edilmiştir. Hücre içinde, 2-fenoksietanol öncelikle sitoplazmada bulunur. 2-Fenoksietanol, mayadan insanlara kadar tüm ökaryotlarda bulunur. 2-Fenoksietanol, fenolden biyosentezlenebilir. 2-Fenoksietanol potansiyel olarak toksik bir bileşiktir.

Fenoksietanol, genellikle kuaterner amonyum bileşikleri ile birlikte kullanılan mikrop öldürücü ve mikrop öldürücü bir glikol eter, fenol eter ve aromatik alkoldür.

Kullanım: Fenoksietanol bir parfüm fiksatifi olarak kullanılır; böcek kovucu; antiseptik; selüloz asetat, boyalar, mürekkepler ve reçineler için bir çözücü; farmasötikler, kozmetikler ve yağlayıcılar için bir koruyucu; balık yetiştiriciliğinde anestezik; ve organik sentezde.

 

Fenoksietanol, formaldehit salan koruyuculara bir alternatiftir. Japonya ve Avrupa Birliği'nde kozmetikteki konsantrasyonu% 1 ile sınırlıdır.

Üretim: Fenoksietanol, örneğin alkali metal hidroksitlerin veya alkali metal borohidritlerin varlığında fenolün hidroksietilasyonu (Williamson sentezi) ile üretilir.

Etkinlik: Fenoksietanol, gram-negatif ve gram-pozitif bakterilere ve Candida albicans mayasına karşı etkilidir.

Güvenlik: Fenoksietanol bir aşı koruyucusu ve potansiyel bir alerjendir ve enjeksiyon bölgesinde nodüler bir reaksiyona neden olabilir. NMDAR aracılı iyon akımlarını tersine çevrilebilir şekilde engeller.

Yutulması bebeklerde merkezi sinir sistemi ve solunum depresyonu, kusma ve ishale neden olabilir, özellikle klorfenesin ile kombine edildiğinde

 

Fenoksietanol, kişisel bakım formülasyonlarında en yaygın olarak kullanılan dünya çapında onaylanmış koruyucudur. Çoğu formülasyon tipinde kullanımı son derece kolaydır ve kimyasal olarak çok kararlıdır. Fenoksietanol, bakterilere, mayalara ve küflere karşı geniş bir antimikrobiyal aktiviteye sahiptir. Formülasyonlarda tipik kullanım seviyesi% 0,5 - 0,8'dir ve genellikle Etilheksil gliserin, Heksilen glikol, Benzil alkol, Benzoik asit, Potasyum sorbat, Dehidroasetik asit, Klorfenesin veya Kapril glikol gibi diğer koruyucularla birleştirilir. Avrupa Ekonomik Topluluğu (AET). Kozmetik Türevi ve Avrupa Birliği'nin Kozmetik Yönetmeliği,% 1'e varan konsantrasyonlarda Fenoksietanolü onayladı.

UYGULAMALAR: Cilt bakımı - Makyaj - Saç bakımı - Deodorant - Tuvalet malzemeleri - Güneş bakımı - Vücut bakımı - Kokular - Islak mendiller

FORMÜLASYON VE TAVSİYELER: Fenoksietanol, kişisel bakım formülasyonlarında en yaygın olarak kullanılan dünya çapında onaylanmış koruyucudur. Çoğu formülasyon tipinde kullanımı son derece kolaydır ve kimyasal olarak çok kararlıdır. Fenoksietanol, bakterilere, mayalara ve küflere karşı geniş bir antimikrobiyal aktiviteye sahiptir. Formülasyonlarda tipik kullanım seviyesi% 0,5 - 0,8'dir ve genellikle

Etilheksil gliserin, Heksilen glikol, Benzil alkol, Benzoik asit, Potasyum sorbat, Dehidroasetik asit, Klorfenesin veya Kapril glikol gibi diğer koruyucularla. Avrupa Ekonomik Topluluğu (EEC) Kozmetik Türevi ve Avrupa Birliği Kozmetik Yönetmeliği,% 1'e varan konsantrasyonlarda Fenoksietanolü onayladı.

 

Kimyasal formül: C8H10O2

Molar kütle: 138.166 g · mol − 1

Görünüm: Renksiz yağlı sıvı

Koku: soluk gül benzeri

Yoğunluk: 1.102 g / cm3

Erime noktası: −2 ° C (28 ° F; 271 K)

Kaynama noktası: 247 ° C (477 ° F; 520 K)

Suda çözünürlük: 26 g / kg

Çözünürlük: Kloroform, Alkali, dietil eter: çözünür

Fıstık yağında çözünürlük: biraz

Zeytinyağında çözünürlük: biraz

Asetonda çözünürlük: karışabilir

Etanolde çözünürlük: karışabilir

Gliserol içinde çözünürlük: karışabilir

Buhar basıncı: 0,001 kPa (0,00015 psi)

Termal iletkenlik: 0.169 W / (m⋅K)

Kırılma indisi (nD): 1.534 (20 ℃)

 

Fenoksietanol, kozmetik ürünlerde koruyucu olarak ve ayrıca parfüm ve sabunlarda stabilizatör olarak kullanılır. Fenoksietanole maruz kalma egzamadan farklı reaksiyonlarla ilişkilendirilmiştir.

 şiddetli, hayatı tehdit eden alerjik reaksiyonlara. Fenoksietanole bebek ağızdan maruz kalma, sinir sistemi işlevini akut olarak etkileyebilir.

 

BULUNANLAR: Nemlendirici, göz farı, fondöten, güneş kremi, saç kremi, maskara, göz kalemi, şampuan, dudak parlatıcısı, kapatıcı, vücut yıkama, el kremi, allık, saç rengi, saç spreyi, dudak kremi,

 losyon, oje, bebek mendilleri, bebek losyonları ve sabunları, sabun (sıvı ve kalıp), tıraş kremi, deodorant, diş macunu, koku, epilasyon mumları, el dezenfektanı ve ultrason jeli.

FENOKSİETANOL NEDİR? Fenoksietanol, bakteri büyümesini sınırlamak için kozmetik ürünlerde koruyucu olarak kullanılır. 43 kozmetik ürün üzerinde yapılan bir inceleme, yalnızca yüzde 25'inin

ürünlerin fenoksietanol konsantrasyonları yüzde 0.6'dan fazla ve ortalama fenoksietanol konsantrasyonu yüzde 0.46 idi. [5] Fenoksietanol de stabilize etmek için kullanılır.

parfüm ve sabunlarda bulunan bileşenler.

 

Fenoksietanol, gül benzeri hafif bir kokuya sahip yağlı, hafif yapışkan bir sıvıdır. Cilt bakımı, göz makyajı, kokular, allık, fondötenler, ruj, banyo sabunları ve deterjanlar gibi çok çeşitli hem bırakılan hem de durulanan kozmetiklerde ve kişisel bakım ürünlerinde koruyucu olarak kullanılır. Fenoksietanol, bu ürünlerde kullanıldığı kadar güvenli olduğu sonucuna varan dünya çapındaki uzmanlar tarafından incelenmiştir.

 

Neden kozmetik ve kişisel bakım ürünlerinde kullanılır?

Fenoksietanol 1950'lerden beri kozmetik ve kişisel bakım ürünlerinde koruyucu olarak güvenle kullanılmaktadır. Gıda gibi ürünlerin bozulmasına neden olabilecek mantar, bakteri ve maya oluşumunu önlemede oldukça etkilidir. Koruyucuların kullanılması, ürünlerin raf ömrünü ve güvenliğini artırır.

 

Su içeren ürünler, çevrede doğal olarak bulunan bakteri ve mantarların neden olduğu küf, renk değişikliği veya hoş olmayan kokulara karşı hassastır. Kozmetikler kullanıldıkça, ciltle ve cilde temas eden aplikatörlerle temas ederler ve bu da ürünü bu zararlı mikroorganizmalara potansiyel olarak maruz bırakır.

 

Belirli koşullar altında, yetersiz korunan bir ürün kontamine olabilir ve bu da tahriş veya enfeksiyon gibi sağlık sorunlarına neden olabilir. Mikroorganizmalarla kirlenmiş ürünler, ürünün performansını, görünüşünü, hissini ve koktuğunu da olumsuz etkileyebilir. Fenoksietanol gibi koruyucular bu tür sorunları önlemeye yardımcı olur.

 

2-fenoksietanol, bir 2-hidroksietil grubu ile oksijen üzerinde ikame edilmiş fenol olan aromatik bir eterdir. Antiinfektif ajan ve merkezi sinir sistemi depresanı olarak rol oynar. Hidroksieter, birincil alkol ve aromatik eterdir. Bir fenolden türemiştir.

Etilen glikol fenil eter, hoş bir kokuya sahip renksiz bir sıvıdır. Yoğunluk 1.02 g / cm3. Tahriş edici

 

 

 

 

CAS Number: 122-99-6; IUPAC name: 2-Phenoxyethanol; Phenoxyethanol; Ethylene glycol monophenyl ether; Phenoxytolarosol;Dowanol EP / EPH; Protectol PE; Emery 6705; Rose ether;1-Hydroxy-2-phenoxyethane

;β-hydroxyethyl phenyl ether; Phenyl cellosolve;Ethylene glycol phenyl ether;2-PHENOXYETHANOL; Cas No: 122-99-6; Phenoxyethanol; Ethylene glycol monophenyl ether; Ethanol, 2-phenoxy-; Phenyl cellosolve; Phenoxytol; Phenoxethol; Phenoxetol; Ethylene glycol phenyl ether; Phenoxyethyl alcohol

; 2-Phenoxyethan-1-Ol; 1-Hydroxy-2-phenoxyethane; Rose ether; Phenylmonoglycol ether; Arosol; Dowanol EP; 2-Phenoxyethyl alcohol; Glycol monophenyl ether; 2-Hydroxyethyl phenyl ether; Phenylglycol

;Fenyl-cellosolve; 2-Fenoxyethanol; Dowanol EPH; 2-Phenoxy-ethanol; Emery 6705; Emeressence 1160; Fenylcelosolv; Marlophen P; beta-Hydroxyethyl phenyl ether; 2-phenoxy ethanol;2-phenoxyethanol; Emuclens;Erisept; ethylene glycol monophenyl ether; phenoxethol; phenoxyethanol

 

2-Phenoxyethanol, also known as phenyl cellosolve or phenoxytol, belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring. 2-Phenoxyethanol exists as a solid, soluble (in water), and an extremely weak acidic (essentially neutral) compound (based on its pKa). 2-Phenoxyethanol has been detected in multiple biofluids, such as feces and saliva. Within the cell, 2-phenoxyethanol is primarily located in the cytoplasm. 2-Phenoxyethanol exists in all eukaryotes, ranging from yeast to humans. 2-Phenoxyethanol can be biosynthesized from phenol. 2-Phenoxyethanol is a potentially toxic compound.

Phenoxyethanol is a germicidal and germistatic glycol ether, phenol ether, and aromatic alcohol often used together with quaternary ammonium compounds.

Use: Phenoxyethanol is used as a perfume fixative; an insect repellent; an antiseptic; a solvent for cellulose acetate, dyes, inks, and resins; a preservative for pharmaceuticals, cosmetics and lubricants; an anesthetic in fish aquaculture; and in organic synthesis.

 

Phenoxyethanol is an alternative to formaldehyde-releasing preservatives.In Japan and the European Union, its concentration in cosmetics is restricted to 1%.

Production: Phenoxyethanol is produced by the hydroxyethylation of phenol (Williamson synthesis), for example, in the presence of alkali-metal hydroxides or alkali-metal borohydrides.

Efficacy: Phenoxyethanol is effective against gram-negative and gram-positive bacteria, and the yeast Candida albicans

Safety: Phenoxyethanol is a vaccine preservative and potential allergen, which may result in a nodular reaction at the site of injection. It reversibly inhibits NMDAR-mediated ion currents.

Ingestion may cause central nervous system and respiratory depression, vomiting and diarrhea in infants, particularly when combined with chlorphenesin

 

Phenoxyethanol, is the most commonly used globally-approved preservative in personal care formulations. It is extremely easy to use in most types of formulations and is chemically very stable. Phenoxyethanol

has a broad spectrum antimicrobial activity against bacteria, yeasts, and mold. The typical use level in formulations is 0,5 – 0,8%, and it is often combined with other preservatives, like Ethylhexyl glycerin, Hexylene glycol, Benzyl alcohol, Benzoic acid, Potassium

sorbate, Dehydroacetic acid, Chlorphenesin or Capryl glycol. The European Economic Community (EEC). Cosmetics Derivative and the Cosmetics Regulation of the European Union approved Phenoxyethanol in concentrations up 1%.

APPLICATIONS: Skin care - Make up - Hair care – Deodorant- ToiletriesCleansers- Sun care - Body care – Fragrances – Wet wipes

FORMULATION AND RECOMMENDATIONS: Phenoxyethanol, is the most commonly used globally-approved preservative in personal care formulations. It is extremely easy to use in most types of formulations and is chemically very stable. Phenoxyethanol

has a broad spectrum antimicrobial activity against bacteria, yeasts, and mold. The typical use level in formulations is 0,5 – 0,8%, and it is often combined

with other preservatives, like Ethylhexyl glycerin, Hexylene glycol, Benzyl alcohol, Benzoic acid, Potassium sorbate, Dehydroacetic acid, Chlorphenesin or Capryl glycol. The European Economic Community (EEC)

Cosmetics Derivative and the Cosmetics Regulation of the European Union approved Phenoxyethanol in concentrations up 1%.

 

Chemical formula: C8H10O2

Molar mass: 138.166 g·mol−1

Appearance: Colorless oily liquid

Odor: faint rose-like

Density: 1.102 g/cm3

Melting point: −2 °C (28 °F; 271 K)

Boiling point: 247 °C (477 °F; 520 K)

Solubility in water: 26 g/kg

Solubility: Chloroform, Alkali, diethyl ether: soluble

Solubility in peanut oil: slightly

Solubility in olive oil: slightly

Solubility in acetone: miscible

Solubility in ethanol: miscible

Solubility in glycerol: miscible

Vapor pressure: 0.001 kPa (0.00015 psi)

Thermal conductivity: 0.169 W/(m⋅K)

Refractive index (nD): 1.534 (20 ℃)

 

Phenoxyethanol is used as a preservative in cosmetic products and also as a stabilizer in perfumes and soaps. Exposure to phenoxyethanol has been linked to reactions ranging from eczema

 to severe, life-threatening allergic reactions. Infant oral exposure to phenoxyethanol can acutely affect nervous system function.

 

FOUND IN: Moisturizer, eye shadow, foundation, sunscreen, conditioner, mascara, eye liner, shampoo, lip gloss, concealer, body wash, hand cream, blush, hair color, hair spray, lip balm,

 lotion, nail polish, baby wipes, baby lotions and soaps, soap (liquid and bar), shaving cream, deodorant, toothpaste, fragrance, hair removal waxes, hand sanitizer and ultrasound gel.

WHAT IS PHENOXYETHANOL? Phenoxyethanol is used as a preservative in cosmetic products to limit bacterial growth. A review of 43 cosmetic products demonstrated that only 25 percent of 

the products had concentrations of phenoxyethanol greater than 0.6 percent and the mean concentration of phenoxyethanol was 0.46 percent.[5] Phenoxyethanol is also used as to stabilize 

components found in perfumes and soaps.

 

 

What Is It?

Phenoxyethanol is an oily, slightly sticky liquid with a faint rose-like scent. It is used as a preservative in a wide variety of both leave-on and rinse-off cosmetics and personal care products, including skin care, eye makeup, fragrances, blushers, foundations, lipstick, bath soaps, and detergents, among others. Phenoxyethanol has been reviewed by experts worldwide who have concluded it is safe as used in these products.

 

Why is it used in cosmetics and personal care products?

Phenoxyethanol has been used safely since the 1950s as a preservative in cosmetics and personal care products. It is highly effective in preventing the growth of fungi, bacteria, and yeast that could cause products to spoil, just like food. The use of preservatives enhances products’ shelf life and safety.

 

Products that contain water are susceptible to mold, discoloration, or unpleasant odors caused by the bacteria and fungi naturally present in the environment. As cosmetics are used, they come in contact with the skin and applicators that contact the skin, thus potentially exposing the product to these harmful microorganisms.

 

Under certain conditions, an inadequately preserved product can become contaminated, which could cause health problems such as irritation or infection. Products contaminated by microorganisms may also negatively impact how the product performs, looks, feels, and smells. Preservatives like phenoxyethanol help prevent such problems.

 

2-phenoxyethanol is an aromatic ether that is phenol substituted on oxygen by a 2-hydroxyethyl group. It has a role as an antiinfective agent and a central nervous system depressant. It is a hydroxyether, a primary alcohol and an aromatic ether. It derives from a phenol.

Ethylene glycol phenyl ether is a colorless liquid with a pleasant odor. Density 1.02 g / cm3. An irritant.

 

2-PHENOXYETHANOL; Cas No: 122-99-6; Phenoxyethanol; Ethylene glycol monophenyl ether; Ethanol, 2-phenoxy-; Phenyl cellosolve; Phenoxytol; Phenoxethol; Phenoxetol; Ethylene glycol phenyl ether; Phenoxyethyl alcohol

; 2-Phenoxyethan-1-Ol; 1-Hydroxy-2-phenoxyethane; Rose ether; Phenylmonoglycol ether; Arosol; Dowanol EP; 2-Phenoxyethyl alcohol; Glycol monophenyl ether; 2-Hydroxyethyl phenyl ether; Phenylglycol

;Fenyl-cellosolve; 2-Fenoxyethanol; Dowanol EPH; 2-Phenoxy-ethanol; Emery 6705; Emeressence 1160; Fenylcelosolv; Marlophen P; beta-Hydroxyethyl phenyl ether; 2-phenoxy ethanol

Marlophen P 7

Spermicide 741

Tritonyl 45

Ethylan HB 4

EGMPE

Fenylcelosolv [Czech]

2-Fenoxyethanol [Czech]

Fenyl-cellosolve [Czech]

Plastiazan-41 [Russian]

Polyoxyethylene phenol ether

Polyoxyethylene phenyl ether

Phenol-ethylene oxide adduct

MFCD00002857

Glycols, polyethylene, monophenyl ether

Phenoxyethanol [NF]

Polyethylene glycol phenyl ether

.beta.-Hydroxyethyl phenyl ether

HSDB 5595

PHE-G

PHE-S

2-Phenoxyethanol, 99%

EINECS 204-589-7

9004-78-8

.beta.-Phenoxyethyl alcohol

alpha-Phenyl-omega-hydroxypoly(oxy-1,2-ethanediyl)

ethyleneglycol monophenyl ether

Phenoxyethanol (NF)

Poly(oxy-1,2-ethanediyl), alpha-phenyl-omega-hydroxy-

Erisept

Plastiazan-41

CAS-122-99-6

Phenol, ethoxylated

PHG

.beta.-Phenoxyethanol

phenoxy-ethanol

phenylcellosolve

Phenoxyethanolum

CCRIS 9481

Ethylene glycol-monophenyl ether

Dalpad A

2-phenyloxyethanol

Newpol EFP

2-Phenoxyethanol.

2-(phenoxy)ethanol

beta-Hydroxyphenetole

2-phenoxy-1-ethanol

beta-phenoxyethylalcohol

ACMC-1BVYG

2-Phenoxyethanol, 9CI

WLN: Q2OR

EC 204-589-7

SCHEMBL15708

2-Phenoxyethanol, >=99%

4-06-00-00571 (Beilstein Handbook Reference)

Euxyl K 400 (Salt/Mix)

[O]CCOC1=CC=CC=C1

2-PHENOXYETHANOL 500ML

Ethylene glycol mono phenyl ether

C(O)[C]OC1=CC=CC=C1

2-Phenoxyethanol, analytical standard

Fungal Terminator [veterinary] (TN)

Ethylene glycol monophenyl ether, >=90%

ETHANOL,2-PHENOXY MFC8 H10 O2

2-Phenoxyethanol, tested according to Ph.Eur.

Ethylene glycol monophenyl ether, SAJ first grade, >=95.0%

Phenoxyethanol, European Pharmacopoeia (EP) Reference Standard

Phenoxyethanol, United States Pharmacopeia (USP) Reference Standard

2-Phenoxyethanol, Pharmaceutical Secondary Standard; Certified Reference Material

 

 

GLOBAL REGULATORY

EU: EINECS) 204-589-7,(Annex I Index No.) 3-098-00-9

USA: (TSCA)Existing chemical

Canada: (DSL)

China: IECSC) Existing chemica

Japan: Existing chemical:(9)-1277, (3)-558

ASEAN (Indonesia, Malaysia, Philippines, Singapore,

Vietnam, Burma, Cambodia, Thailand, Laos, Brunei): (PICSS)

Existing chemical

South Korea: KE-28257   

Australia (NICNAS – Cosmetics): No limitation

New Zealand: HSR003045

PHENOXYETHANOL

SPECIFICATION

Description: Phenoxyethanol is an oily, slightly sticky

liquid with a faint rose-like odour. It is used as a preservative

in a wide variety of cosmetic and personal care products.

Research shows that this ingredient is safe when used in

these products.

INCI: Phenoxyethanol

EFFICACY

Escherichia coli (bacteria gram negative) -.32%

Pseudomonas aeruginosa (bacteria gram negative) -.32%

Staphylococcus aureus (bacteria gram positive) -.64%

Aspergillus niger (mold) -.32%

Candida albicans (yeast) -.32%

 

 

Phenoxyethanol is a glycol ether used as a preservative in cosmetic products. It is used in many skin care, make-up, hair care products. Because of its anti-bacterial properties, it is also used in baby wipes and hand sanitizer.

PHENOXYETHANOL is classified as :

Preservative

CAS Number 122-99-6

EINECS/ELINCS No: 204-589-7

Restriction (applies to EU only): VI/29

COSING REF No: 36522

PHARMACEUTICAL EUROPEAN NAME: phenoxyethanolum

Chem/IUPAC Name: 2-Phenoxyethanol

 

Consumer products

Preservation of cosmetics, toiletry and household products and their raw materials. Phenoxyethanol is often used in combination with other preservatives and in some cases positive synergetic effects can be obtained. It is also used in acne treatment. Due to its low evaporation, Phenoxyethanol is used as a fixative in perfumes and fragrance.

 

Industrial products

It can be used in water mixable lubricants, in paints and varnishes as coalescing agent and as a modifier in melamine formaldehyde resins. It is used as a solvent in ball pen and printing inks. Phenoxyethanol is used as a striping agent and in the surface treatment of metals as degreaser. Its biostatic abilities is often used in combination with other actives to preserve metal working fluids, glues and industrial adhesives.

 

Safety

Eye contact may cause moderate irritation or moderate corneal injury. Repeated skin contact may result in absorption of harmful amounts. Swallowing small amounts is unlikely to result in injury. Swallowing large amounts may result in injury.

Phenoxyethanol is a high boiling liquid with a low vapor pressure, so exposure to vapors is unlikely at room temperature.

Phenoxyethanol  is thermally stable at typical storage and use temperatures. It can oxidize at elevated temperatures. Phenoxyethanol  is readily biodegradable and has a low potential for bioconcentration. It is practically nontoxic to aquatic organisms.

 

Handling and storage

Contact with eyes  and skin should be avoided. Safety googles must be worn when handling the concentrated product. The product should be stored at seald packaging as supplied, in dry conditions, at temperatures not exceeding 30

Classification according to UN criteria: Not classified as hazardous under transport regulation

 

Packaging & Shelf Life:

Under proper storage conditions the shelf life is 24 month.

 

Health & Safety:

Detailed information on the product can be found in our Material Safety Data Sheet.

 

Phenoxyethanol

Other

Translated names

2-fenoksietanol (hr)

2-Fenoksietanoli (fi)

2-fenoksietanolis (lt)

2-Fenoksietanols (lv)

2-fenoksyetanol (no)

2-fenoksüetanool (et)

2-Fenossietanol (mt)

2-fenossietanolo (it)

2-Fenoxietanol (es)

2-fenoxyetanol (sk)

2-fenoxyethan-1-ol (cs)

2-Fenoxyethanol (nl)

2-phenoxyethanol (da)

2-phénoxyéthanol (fr)

2-φαινοξυ-αιθανόλη (el)

2-φαινοξυαιθανόλ (el)

2-феноксиетанол (bg)

eter monofenylowy glikolu etylenowego (pl)

fenil glicol (it)

fenylglykol (sv)

fenoksietanol(tr)

fenoksi etanol (tr)

fenoksiethanol (tr)

fenoksi ethanol (tr)

CAS names: Ethanol, 2-phenoxy-

Other IUPAC names: 

1-HYDROXY-2-PHENOXYETHANE

2-(phenoxy)ethanol

2-(phenoxyethanol

2-Phenoxy-1-ethanol

2-phenoxyethan-1-ol

2-PhenoxyethanolRD_CLP_122-99-6_Ethanol, 2-phenoxy-_V1_20180112_TS

Ethylene glycol monophenyl ether

Ethylene glycol phenyl ether

 Ethyleneglycol monophenyl ether

SHINING COLOR BLUE EU CONC

Trade names

(2-hydroxy-ethyl)-phenyl-ether (alternative chemical name)

.beta.-Hydroxyethyl phenyl ether

.beta.-Phenoxyethanol

.beta.-Phenoxyethyl alcohol

2-Hydroxyethyl phenyl ether

2-Phenoxyethyl alcohol

Arosol

Beta-phenoxyethylalcohol (alternative chemical name)

Dalpad A

DALPAD™ A Coalescing Agent

Dowanol EP

Dowanol EPh

Dowanol EPH Glycol Ether

DOWANOL™ EPH Glycol Ether

DOWANOL™ EPH GLYCOL ETHER, EXTRA LOW PHENOL GRADE

ENSOLINE

Ethanol, 2-phenoxy- (6CI, 7CI, 8CI, 9CI)

Ethylene glycol monophenyl ether (alternative chemical name)

H 4644

MARLOPHEN P 1 AB

MARLOPHEN P 1 ABn

Marlosol PHE

Monophenylglykol

Phenoxethol

Phenoxetol

Phenoxyethanol (INCI name and CTFA adopted name)

Phenoxyethyl alcohol

Phenyl cellosolve

Protectol EPE (trade name)

Protectol PE (trade name)

SHINING COLOR BLUE, BR BLUE, LT BLUE EU CONC

STERO PE

 

Phenoxyethanol [Wiki]

122-99-6 [RN]

1-Hydroxy-2-phenoxyethane

204-589-7 [EINECS]

2-phenoxyethan-1-ol

2-Phenoxyethanol [ACD/IUPAC Name]

2-Phenoxyethanol [German] [ACD/IUPAC Name]

2-Phenoxy-ethanol

2-Phénoxyéthanol [French] [ACD/IUPAC Name]

DOWANOL(R) EPh

Ethanol, 2-phenoxy- [ACD/Index Name]

Ethylene glycol monophenyl ether

HIE492ZZ3T

KM0350000

PhE [Formula]

PHE-G

Phenoxyethanolum

PHENOXYETHYL ALCOHOL

Phenyl cellosolve

Phenylglycol

PHE-S

PHG

Rose ether

(2-Hydroxyethoxy)benzene

??2-phenoxyethanol

[122-99-6]

1219804-65-5 [RN]

134367-25-2 [RN]

18249-17-7 [RN]

2-(phenoxy)ethanol

200260-63-5 [RN]

21273-38-1 [RN]

268

2-Fenoxyethanol

2-Fenoxyethanol [Czech]

2-Hydroxyethyl phenyl ether

2-PHENOXY ETHANOL

2-Phenoxyethan-1-ol|(2-Hydroxyethoxy)benzene

2-phenoxyethanol 99%

2-phenoxyethanol, ??? 98.5%

2-phenoxyethanol, 94%

2-phenoxyethanol, 99%

2-Phenoxyethanol, 9CI

2-PHENOXYETHANOL-1,1-D2

2-Phenoxyethyl alcohol

2-Phenoxyethyl-1,1,2,2-d4 Alcohol

2-PHENOXYETHYL-2,2-D2 ALCOHOL

2-Phenoxyethyl--d4 Alcohol

37220-49-8 [RN]

4-06-00-00571 (Beilstein Handbook Reference) [Beilstein]

438620-17-8 [RN]

56257-90-0 [RN]

79586-53-1 [RN]

AI3-00752()C

Arosol

BB_SC-2741

C8H10O2

Dalpad A

Diethylene glycol monophenyl ether

Dowanol EP

Dowanol EPH

EGMPE

EINECS 204-589-7

Emeressence 1160

ETHANOL,2-PHENOXY MFC8 H10 O2

Ethylan HB 4

Ethylene glycol mono phenyl ether

ethylene glycol monobenzyl ether

ethylene glycol monophenyl ether 98%

ETHYLENE GLYCOL PHENYL ETHER

Ethylene glycol-monophenyl ether

Ethyleneglycol monophenyl ether

Ethyleneglycol-monophenyl ether

ETYLENEGLYCOL MONOPHENYL ETHER

Euxyl K 400 (Salt/Mix)

Fenyl-cellosolve

Fenyl-cellosolve [Czech]

Fenylcelosolv

Fenylcelosolv [Czech]

Glycol monophenyl ether

Glycols, polyethylene, monophenyl ether

http://www.hmdb.ca/metabolites/HMDB0041607

https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:64275

InChI=1/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H

Jsp001544

Marlophen P

Marlophen P 7

NCGC00090731-02

NCGC00090731-03

Newpol EFP

Phenol, ethoxylated

Phenol-ethylene oxide adduct

Phenoxethol

Phenoxetol

Phenoxydiglycol

phenoxyethanol, reagent

Phenoxyethanol, USP-NF grade

Phenoxyl ethanol

Phenoxytol

Phenylcellosolve

Phenylmonoglycol ether

Plastiazan-41 [Russian]

Polyethylene glycol phenyl ether

Polyoxyethylene phenol ether

Polyoxyethylene phenyl ether

Spermicide 741

STR04582

Tritonyl 45

UNII:HIE492ZZ3T

UNII-HIE492ZZ3T

WLN: Q2OR

α-Phenyl-ω-hydroxypoly(oxy-1,2-ethanediyl)

β-Hydroxyethyl phenyl ether

β-Hydroxyethyl phenyl ether

β-Phenoxyethanol

β-Phenoxyethanol

β-Phenoxyethyl alcohol

β-Phenoxyethyl alcohol

苯氧乙醇 [Chinese]

 

 

 

 

Principaux synonymes

Noms français :

 

1-HYDROXY-2-PHENOXYETHANE

2-Phenoxyethanol

2-PHENOXYETHYL ALCOHOL

ETHANOL, 2-PHENOXY-

ETHER MONOPHENYLIQUE DE L'ETHYLENE GLYCOL

HYDROXY-1 PHENOXY-2 ETHANE

Phenoxy-2 ethanol

Phénoxy-2 éthanol

Phénoxyéthanol

Éther de phényle et d' 2-hydroxyéthyle

Noms anglais :

 

2-Hydroxyethyl phenyl ether

2-Phenoxyethanol

BETA-HYDROXYETHYL PHENYL ETHER

BETA-PHENOXYETHANOL

BETA-PHENOXYETHYL ALCOHOL

Ethylene glycol monophenyl ether

ETHYLENE GLYCOL PHENYL ETHER

GLYCOL MONOPHENYL ETHER

PHENOXYETHYL ALCOHOL

PHENYL CELLOSOLVE

PHENYLMONOGLYCOL ETHER

Utilisation et sources d'émission

Fabrication de cosmétiques, fabrication de chasse-insectes

 

 

 

Numéro CAS: 122-99-6; Nom IUPAC: 2-phénoxyéthanol; Phénoxyéthanol; Éther monophénylique d'éthylène glycol; Phénoxytolarosol, Dowanol EP / EPH; Protectol PE; Emery 6705; Rose éther, 1-hydroxy-2-phénoxyéthane, β-hydroxyéthylphényléther; Phényl cellosolve; éther phénylique d'éthylène glycol; 2-PHÉNOXYÉTHANOL; N ° CAS: 122-99-6; Phénoxyéthanol; Éther monophénylique d'éthylène glycol; Éthanol, 2-phénoxy-; Phenyl cellosolve; Phenoxytol; Phenoxethol; Phenoxetol; Éther phénylique d'éthylène glycol; Alcool phénoxyéthylique

; 2-phénoxyéthan-1-Ol; 1-hydroxy-2-phénoxyéthane; Rose éther; Éther de phénylmonoglycol; Arosol; Dowanol EP; Alcool 2-phénoxyéthylique; Éther monophénylique de glycol; 2-hydroxyéthylphényléther; Phénylglycol

; Fenyl-cellosolve; 2-fénoxyéthanol; Dowanol EPH; 2-phénoxy-éthanol; Emery 6705; Emeressence 1160; Fenylcelosolv; Marlophen P; l'éther bêta-hydroxyéthylphénylique; 2-phénoxy éthanol, 2-phénoxyéthanol; Emuclens, Erisept; l'éther monophénylique d'éthylène glycol; phénoxethol; phénoxyéthanol

 

Le 2-phénoxyéthanol, également connu sous le nom de phényl cellosolve ou phénoxytol, appartient à la classe des composés organiques appelés éthers phénoliques. Ce sont des composés aromatiques contenant un groupe éther substitué par un cycle benzénique. Le 2-phénoxyéthanol existe sous forme de composé solide, soluble (dans l'eau) et extrêmement faible acide (essentiellement neutre) (basé sur son pKa). Le 2-phénoxyéthanol a été détecté dans plusieurs biofluides, tels que les matières fécales et la salive. Dans la cellule, le 2-phénoxyéthanol est principalement situé dans le cytoplasme. Le 2-phénoxyéthanol existe dans tous les eucaryotes, allant de la levure à l'homme. Le 2-phénoxyéthanol peut être biosynthétisé à partir du phénol. Le 2-phénoxyéthanol est un composé potentiellement toxique.

Le phénoxyéthanol est un éther de glycol germicide et germistatique, un éther de phénol et un alcool aromatique souvent utilisés avec des composés d'ammonium quaternaire.

Utilisation: Le phénoxyéthanol est utilisé comme fixateur de parfum; un insectifuge; un antiseptique; un solvant pour l'acétate de cellulose, les colorants, les encres et les résines; un conservateur pour produits pharmaceutiques, cosmétiques et lubrifiants; un anesthésique en pisciculture; et en synthèse organique.

 

Le phénoxyéthanol est une alternative aux conservateurs libérant du formaldéhyde.Au Japon et dans l'Union européenne, sa concentration dans les cosmétiques est limitée à 1%.

Production: Le phénoxyéthanol est produit par l'hydroxyéthylation du phénol (synthèse de Williamson), par exemple, en présence d'hydroxydes de métaux alcalins ou de borohydrures de métaux alcalins.

Efficacité: le phénoxyéthanol est efficace contre les bactéries Gram négatif et Gram positif, et la levure Candida albicans

Innocuité: Le phénoxyéthanol est un agent de conservation du vaccin et un allergène potentiel, qui peut entraîner une réaction nodulaire au site d'injection. Il inhibe de manière réversible les courants ioniques médiés par NMDAR.

L'ingestion peut provoquer une dépression du système nerveux central et respiratoire, des vomissements et de la diarrhée chez les nourrissons, en particulier lorsqu'elle est associée à la chlorphénésine

 

Le phénoxyéthanol est le conservateur le plus couramment utilisé dans le monde dans les formulations de soins personnels. Il est extrêmement facile à utiliser dans la plupart des types de formulations et est chimiquement très stable. Le phénoxyéthanol a une activité antimicrobienne à large spectre contre les bactéries, les levures et les moisissures. Le niveau d'utilisation typique dans les formulations est de 0,5 à 0,8%, et il est souvent combiné avec d'autres conservateurs, comme l'éthylhexyl glycérine, l'hexylène glycol, l'alcool benzylique, l'acide benzoïque, le sorbate de potassium, l'acide déhydroacétique, la chlorphénésine ou le capryl glycol. La Communauté économique européenne (CEE). Le dérivé cosmétique et le règlement cosmétique de l'Union européenne ont approuvé le phénoxyéthanol à des concentrations en hausse de 1%.

APPLICATIONS: Soin de la peau - Maquillage - Soin des cheveux - Déodorant - Produits de toilette Nettoyants - Soin solaire - Soin du corps - Parfums - Lingettes humides

FORMULATION ET RECOMMANDATIONS: Le phénoxyéthanol est le conservateur le plus couramment utilisé dans le monde dans les formulations de soins personnels. Il est extrêmement facile à utiliser dans la plupart des types de formulations et est chimiquement très stable. Le phénoxyéthanol a une activité antimicrobienne à large spectre contre les bactéries, les levures et les moisissures. Le niveau d'utilisation typique dans les formulations est de 0,5 à 0,8%, et il est souvent combiné

avec d'autres conservateurs, comme l'éthylhexyl glycérine, l'hexylène glycol, l'alcool benzylique, l'acide benzoïque, le sorbate de potassium, l'acide déhydroacétique, la chlorphénésine ou le capryl glycol. Le dérivé cosmétique de la Communauté économique européenne (CEE) et le règlement cosmétique de l'Union européenne ont approuvé le phénoxyéthanol à des concentrations allant jusqu'à 1%.

 

Formule chimique: C8H10O2

Masse moléculaire: 138,166 g · mol − 1

Apparence: Liquide huileux incolore

Odeur: légèrement rose

Densité: 1,102 g / cm3

Point de fusion: -2 ° C (28 ° F; 271 K)

Point d'ébullition: 247 ° C (477 ° F; 520 K)

Solubilité dans l'eau: 26 g / kg

Solubilité: Chloroforme, alcali, éther diéthylique: soluble

Solubilité dans l'huile d'arachide: légèrement

Solubilité dans l'huile d'olive: légèrement

Solubilité dans l'acétone: miscible

Solubilité dans l'éthanol: miscible

Solubilité dans le glycérol: miscible

Pression de vapeur: 0,001 kPa (0,00015 psi)

Conductivité thermique: 0,169 W / (m⋅K)

Indice de réfraction (nD): 1,534 (20 ℃)

 

Le phénoxyéthanol est utilisé comme conservateur dans les produits cosmétiques et également comme stabilisant dans les parfums et les savons. L'exposition au phénoxyéthanol a été liée à des réactions allant de l'eczéma

 à des réactions allergiques graves et potentiellement mortelles. L'exposition orale du nourrisson au phénoxyéthanol peut affecter gravement le fonctionnement du système nerveux.

 

TROUVÉ DANS: Hydratant, ombre à paupières, fond de teint, crème solaire, revitalisant, mascara, eye-liner, shampooing, brillant à lèvres, correcteur, gel douche, crème pour les mains, blush, couleur de cheveux, laque pour cheveux, baume à lèvres,

 lotion, vernis à ongles, lingettes pour bébé, lotions et savons pour bébé, savon (liquide et pain), crème à raser, déodorant, dentifrice, parfum, cires d'épilation, désinfectant pour les mains et gel à ultrasons.

QU'EST-CE QUE LE PHÉNOXYÉTHANOL? Le phénoxyéthanol est utilisé comme conservateur dans les produits cosmétiques pour limiter la croissance bactérienne. Un examen de 43 produits cosmétiques a démontré que seulement 25% des

les produits avaient des concentrations de phénoxyéthanol supérieures à 0,6 pour cent et la concentration moyenne de phénoxyéthanol était de 0,46 pour cent. [5] Le phénoxyéthanol est également utilisé pour stabiliser

composants trouvés dans les parfums et les savons.

 

 

Qu'Est-ce que c'est?

Le phénoxyéthanol est un liquide huileux légèrement collant avec une légère odeur de rose. Il est utilisé comme conservateur dans une grande variété de cosmétiques et de produits de soins personnels sans rinçage et à rincer, notamment les soins de la peau, le maquillage des yeux, les parfums, les fards à joues, les fonds de teint, les rouges à lèvres, les savons de bain et les détergents, entre autres. Le phénoxyéthanol a été examiné par des experts du monde entier qui ont conclu qu'il est sans danger tel qu'il est utilisé dans ces produits.

 

Pourquoi est-il utilisé dans les cosmétiques et les produits de soins personnels?

Le phénoxyéthanol est utilisé en toute sécurité depuis les années 1950 comme conservateur dans les cosmétiques et les produits de soins personnels. Il est très efficace pour empêcher la croissance de champignons, de bactéries et de levures qui pourraient altérer les produits, tout comme les aliments. L’utilisation d’agents de conservation améliore la durée de conservation et la sécurité des produits.

 

Les produits contenant de l'eau sont sensibles aux moisissures, à la décoloration ou aux odeurs désagréables causées par les bactéries et les champignons naturellement présents dans l'environnement. Lors de l'utilisation de produits cosmétiques, ils entrent en contact avec la peau et les applicateurs qui entrent en contact avec la peau, exposant ainsi potentiellement le produit à ces micro-organismes nocifs.

 

Dans certaines conditions, un produit mal conservé peut devenir contaminé, ce qui pourrait entraîner des problèmes de santé tels qu'une irritation ou une infection. Les produits contaminés par des microorganismes peuvent également avoir un impact négatif sur les performances, l'apparence, la sensation et l'odeur du produit. Les conservateurs comme le phénoxyéthanol aident à prévenir de tels problèmes.

 

Le 2-phénoxyéthanol est un éther aromatique qui est un phénol substitué sur l'oxygène par un groupe 2-hydroxyéthyle. Il a un rôle d'agent anti-infectieux et de dépresseur du système nerveux central. C'est un hydroxyéther, un alcool primaire et un éther aromatique. Il dérive d'un phénol.

L'éther phénylique de l'éthylène glycol est un liquide incolore à l'odeur agréable. Densité 1,02 g / cm3. Un irritant

 

 

 

Phenoxyethanol

Other

Translated names

2-fenoksietanol (hr)

2-Fenoksietanoli (fi)

2-fenoksietanolis (lt)

2-Fenoksietanols (lv)

2-fenoksyetanol (no)

2-fenoksüetanool (et)

2-Fenossietanol (mt)

2-fenossietanolo (it)

2-Fenoxietanol (es)

2-fenoxyetanol (sk)

2-fenoxyethan-1-ol (cs)

2-Fenoxyethanol (nl)

2-phenoxyethanol (da)

2-phénoxyéthanol (fr)

2-φαινοξυ-αιθανόλη (el)

2-φαινοξυαιθανόλ (el)

2-феноксиетанол (bg)

eter monofenylowy glikolu etylenowego (pl)

fenil glicol (it)

fenylglykol (sv)

fenoksietanol(tr)

fenoksi etanol (tr)

fenoksiethanol (tr)

fenoksi ethanol (tr)

CAS names: Ethanol, 2-phenoxy-

Other IUPAC names: 

1-HYDROXY-2-PHENOXYETHANE

2-(phenoxy)ethanol

2-(phenoxyethanol

2-Phenoxy-1-ethanol

2-phenoxyethan-1-ol

2-PhenoxyethanolRD_CLP_122-99-6_Ethanol, 2-phenoxy-_V1_20180112_TS

Ethylene glycol monophenyl ether

Ethylene glycol phenyl ether

 Ethyleneglycol monophenyl ether

SHINING COLOR BLUE EU CONC

Trade names

(2-hydroxy-ethyl)-phenyl-ether (alternative chemical name)

.beta.-Hydroxyethyl phenyl ether

.beta.-Phenoxyethanol

.beta.-Phenoxyethyl alcohol

2-Hydroxyethyl phenyl ether

2-Phenoxyethyl alcohol

Arosol

Beta-phenoxyethylalcohol (alternative chemical name)

Dalpad A

DALPAD™ A Coalescing Agent

Dowanol EP

Dowanol EPh

Dowanol EPH Glycol Ether

DOWANOL™ EPH Glycol Ether

DOWANOL™ EPH GLYCOL ETHER, EXTRA LOW PHENOL GRADE

ENSOLINE

Ethanol, 2-phenoxy- (6CI, 7CI, 8CI, 9CI)

Ethylene glycol monophenyl ether (alternative chemical name)

H 4644

MARLOPHEN P 1 AB

MARLOPHEN P 1 ABn

Marlosol PHE

Monophenylglykol

Phenoxethol

Phenoxetol

Phenoxyethanol (INCI name and CTFA adopted name)

Phenoxyethyl alcohol

Phenyl cellosolve

Protectol EPE (trade name)

Protectol PE (trade name)

SHINING COLOR BLUE, BR BLUE, LT BLUE EU CONC

STERO PE

 

Phenoxyethanol [Wiki]

122-99-6 [RN]

1-Hydroxy-2-phenoxyethane

204-589-7 [EINECS]

2-phenoxyethan-1-ol

2-Phenoxyethanol [ACD/IUPAC Name]

2-Phenoxyethanol [German] [ACD/IUPAC Name]

2-Phenoxy-ethanol

2-Phénoxyéthanol [French] [ACD/IUPAC Name]

DOWANOL(R) EPh

Ethanol, 2-phenoxy- [ACD/Index Name]

Ethylene glycol monophenyl ether

HIE492ZZ3T

KM0350000

PhE [Formula]

PHE-G

Phenoxyethanolum

PHENOXYETHYL ALCOHOL

Phenyl cellosolve

Phenylglycol

PHE-S

PHG

Rose ether

(2-Hydroxyethoxy)benzene

??2-phenoxyethanol

[122-99-6]

1219804-65-5 [RN]

134367-25-2 [RN]

18249-17-7 [RN]

2-(phenoxy)ethanol

200260-63-5 [RN]

21273-38-1 [RN]

268

2-Fenoxyethanol

2-Fenoxyethanol [Czech]

2-Hydroxyethyl phenyl ether

2-PHENOXY ETHANOL

2-Phenoxyethan-1-ol|(2-Hydroxyethoxy)benzene

2-phenoxyethanol 99%

2-phenoxyethanol, ??? 98.5%

2-phenoxyethanol, 94%

2-phenoxyethanol, 99%

2-Phenoxyethanol, 9CI

2-PHENOXYETHANOL-1,1-D2

2-Phenoxyethyl alcohol

2-Phenoxyethyl-1,1,2,2-d4 Alcohol

2-PHENOXYETHYL-2,2-D2 ALCOHOL

2-Phenoxyethyl--d4 Alcohol

37220-49-8 [RN]

4-06-00-00571 (Beilstein Handbook Reference) [Beilstein]

438620-17-8 [RN]

56257-90-0 [RN]

79586-53-1 [RN]

AI3-00752()C

Arosol

BB_SC-2741

C8H10O2

Dalpad A

Diethylene glycol monophenyl ether

Dowanol EP

Dowanol EPH

EGMPE

EINECS 204-589-7

Emeressence 1160

ETHANOL,2-PHENOXY MFC8 H10 O2

Ethylan HB 4

Ethylene glycol mono phenyl ether

ethylene glycol monobenzyl ether

ethylene glycol monophenyl ether 98%

ETHYLENE GLYCOL PHENYL ETHER

Ethylene glycol-monophenyl ether

Ethyleneglycol monophenyl ether

Ethyleneglycol-monophenyl ether

ETYLENEGLYCOL MONOPHENYL ETHER

Euxyl K 400 (Salt/Mix)

Fenyl-cellosolve

Fenyl-cellosolve [Czech]

Fenylcelosolv

Fenylcelosolv [Czech]

Glycol monophenyl ether

Glycols, polyethylene, monophenyl ether

http://www.hmdb.ca/metabolites/HMDB0041607

https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:64275

InChI=1/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H

Jsp001544

Marlophen P

Marlophen P 7

NCGC00090731-02

NCGC00090731-03

Newpol EFP

Phenol, ethoxylated

Phenol-ethylene oxide adduct

Phenoxethol

Phenoxetol

Phenoxydiglycol

phenoxyethanol, reagent

Phenoxyethanol, USP-NF grade

Phenoxyl ethanol

Phenoxytol

Phenylcellosolve

Phenylmonoglycol ether

Plastiazan-41 [Russian]

Polyethylene glycol phenyl ether

Polyoxyethylene phenol ether

Polyoxyethylene phenyl ether

Spermicide 741

STR04582

Tritonyl 45

UNII:HIE492ZZ3T

UNII-HIE492ZZ3T

WLN: Q2OR

α-Phenyl-ω-hydroxypoly(oxy-1,2-ethanediyl)

β-Hydroxyethyl phenyl ether

β-Hydroxyethyl phenyl ether

β-Phenoxyethanol

β-Phenoxyethanol

β-Phenoxyethyl alcohol

β-Phenoxyethyl alcohol

苯氧乙醇 [Chinese]

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