Cas No : 643-79-8
Kimyasal sterilant ( dezenfeksiyon) alanında, ftalaldehit, glutaraldehit ile karşılaştırıldığında, gözleri ve nazal geçişleri tahriş etmez, ancak geniş bir pH aralığında (3-9) mükemmel stabiliteye sahiptir, bu, maruziyetin izlenmesi gerektirmez ve zar zor algılanabilir bir kokuya sahiptir. Ancak ftaldialdehit, korunmasız cilt dahil proteinleri griye boyar. Bu nedenle, kontamine aletler, kontamine ekipman ve kimyasallarla çalışırken eldiven, göz koruması, sıvıya dayanıklı önlükler kullanılarak ele alınmalıdır.
Saf orto-ftalaldehite nadiren rastlanır. Dezenfektan olarak kullanıldığında, yaklaşık% 0,55 konsantrasyona sahip sulu bir çözelti formunda gelir. Ticari solüsyonlar, sitrik asit ve fosfatlar, koruyucular ve renklendiriciler gibi pH'larını stabilize etmeye yardımcı olan katkı maddeleri içerir.
Kullanım ve emisyon kaynakları:
Orto-ftalaldehit, öncelikle endoskoplar gibi dental veya tıbbi aletler için yüksek verimli kimyasal dezenfektan olarak kullanılır. Genellikle glutaraldehite göre daha güvenli bir alternatif olarak kabul edilir.
Ayrıca laboratuvarda birincil aminlerin ve tiyollerin florometrik analizleri için bir reaktif olarak kullanılır.
Ftalaldehit (bazen o-ftalaldehit veya orto-ftalaldehit, OPA), C6H4 (CHO) 2 formülüne sahip kimyasal bileşiktir. Ftalik asitle ilgili üç benzen dikarbaldehit izomerinden biridir. Bu soluk sarı katı, heterosiklik bileşiklerin sentezinde bir yapı taşı ve amino asitlerin analizinde bir reaktiftir. OPA, pH <11.5 olan su çözeltisinde çözünür. Çözeltileri, UV aydınlatması ve havaya maruz kalması üzerine bozulur.
Dezenfeksiyonda kullanıldığı gibi süt proteinlerinin belirlenmesinde de opa kullanılmaktadır. Ayrıca OPA genellikle 2-merkaptoetanol varlığında ve pH 9.5 de peptit ve proteinlerin primer amin gruplarıyla oldukça floresans bileşikler olan izoindolleri meydana getirir.
Kullanım ve emisyon kaynakları:
Orto-ftalaldehit, öncelikle endoskoplar gibi dental veya tıbbi aletler için yüksek verimli kimyasal dezenfektan olarak kullanılır. Genellikle glutaraldehite göre daha güvenli bir alternatif olarak kabul edilir.
Ayrıca laboratuvarda birincil aminlerin ve tiyollerin florometrik analizleri için bir reaktif olarak kullanılır.
Ftalaldehit (bazen o-ftalaldehit veya orto-ftalaldehit, OPA), C6H4 (CHO) 2 formülüne sahip kimyasal bileşiktir. Ftalik asitle ilgili üç benzen dikarbaldehit izomerinden biridir. Bu soluk sarı katı, heterosiklik bileşiklerin sentezinde bir yapı taşı ve amino asitlerin analizinde bir reaktiftir. OPA, pH <11.5 olan su çözeltisinde çözünür. Çözeltileri, UV aydınlatması ve havaya maruz kalması üzerine bozulur.
Biyokimya
OPA, kapiler elektroforez ve kromatografi ile özellikle proteinlerde, peptidlerde ve amino asitlerde bulunan solüsyondaki aminleri veya sülfhidrilleri test etmek için çok hassas bir floresan reaktifinde kullanılır. OPA, tiyollerin varlığında izoelektrik noktası Pi'nin üzerindeki birincil aminlerle spesifik olarak reaksiyona girer. OPA ayrıca n-propilamin veya 2-aminoetanol gibi bir amin varlığında tiyollerle reaksiyona girer. Yöntem spektrometriktir (330-390 nm'de (maks. 340 nm) eksitasyon ile 436-475 nm'de (maks. 455 nm) floresan emisyon).
O-Ftalaldehit (OPA), birincil aminlerle floresan konjugasyon ürünleri oluşturan kimyasal bir reaktiftir. Vücut sıvılarında nanogram miktarlarında birçok biyojenik amin, peptit ve proteinin tespiti için kullanılır. O-Ftalaldehit, belirli böbrek ve metabolik hastalıkların tanı ve tedavisi için kan üre nitrojenini (BUN) tespit etmek için test sistemlerinde kullanılmak üzere FDA tarafından onaylanmıştır. OPA aynı zamanda bilinen bir dezenfektandır ve ısıya duyarlı tıbbi aletlerin yüksek seviyede sterilizasyonu için onaylanmıştır ve sağlık sektöründe glutaraldehit yerine giderek daha fazla kullanılmaktadır. OPA ayrıca bir iç mekan antimikrobiyal pestisit olarak kullanım için onaylanmıştır; farmasötiklerin, ilaçların ve diğer organik bileşiklerin sentezi için bir ara ürün.
Dezenfeksiyon
OPA, genellikle Cidex OPA veya TD-8 markaları altında satılan tıbbi aletler için yüksek seviye dezenfektan olarak kullanılır. OPA ile dezenfeksiyon, spekül, laringeal aynalar ve dahili ultrason probları gibi mukoza zarları veya kırık deri ile temas eden yarı kritik aletler için endikedir.
Poli (ftalaldehit)
OPA polimerize edilebilir. Polimerde, oksijen atomlarından biri aynı ftalaldehit biriminin diğer halka olmayan karbonuna bir köprü oluştururken, diğeri başka bir ftalaldehit biriminin halka olmayan karbonuna köprüler. Poli (ftalaldehit), bir fotorezist yapımında kullanılır.
Şarap yapımında
O-Phthaldialdehyde Assay (NOPA) yoluyla Azot, fermantasyonu başarıyla tamamlamak için şarap mayasının ihtiyaç duyduğu maya asimile edilebilir nitrojeni (veya YAN) ölçmek için şarap yapımında kullanılan yöntemlerden biridir.
Cas no: 643-79-8;PHTHALALDEHYDE;PHTHARAL; o-Phthaldialdehyde; Benzene-1,2-dicarboxaldehyde; 1,2-Benzenedicarboxaldehyde; Phthaldialdehyde; Phthalic aldehyde; Phthalic dialdehyde; ortho-Phthalaldehyde; Phthalyldicarboxaldehyde; o-Phthaldehyde; benzene-1,2-dicarbaldehyde; Phthalic dicarboxaldehyde; Phthalaldialdehyde;o-Phthalicdicarboxaldehyde; 1,2-Diformylbenzene; 2-PHTHALALDEHYDE
In chemical sterilant field, phthalaldehyde, compare with glutaraldehyde, is not irritant to the eyes and nasal passages but has excellent stability over a wide range of pH (3-9), which does not require exposure monitoring, and has a barely perceptible odor. But phthaldialdehyde stains proteins gray including unprotected skin. Thus, it must be handled with use of gloves, eye protection, fluid-resistant gowns when handling contaminated instruments, contaminated equipment, and chemicals.
Pure ortho-phthalaldehyde is rarely encountered. When used as a disinfectant, it comes in the form of an aqueous solution with a concentration of approximately 0.55%. Commercial solutions contain additives that help stabilize their pH, such as citric acid and phosphates, preservatives and colorants.
Use and sources of emission:
Ortho-phthalaldehyde is primarily used as a high-efficiency chemical disinfectant for dental or medical instruments, such as endoscopes. It is often considered a safer alternative to glutaraldehyde.
It is also used in the laboratory, as a reagent for fluorometric analyzes of primary amines and thiols.
Phthalaldehyde (sometimes also o-phthalaldehyde or ortho-phthalaldehyde, OPA) is the chemical compound with the formula C6H4(CHO)2. It is one of three isomers of benzene dicarbaldehyde, related to phthalic acid. This pale yellow solid is a building block in the synthesis of heterocyclic compounds and a reagent in the analysis of amino acids. OPA dissolves in water solution at pH < 11.5. Its solutions degrade upon UV illumination and exposure to air.
o-PHTHALALDEHYDE
PRODUCT IDENTIFICATION
CAS NO. 643-79-8
o-PHTHALALDEHYDE
EINECS NO. 211-402-2
FORMULA C6H4-1,2-(CHO)2
MOL WT. 134.12
SYNONYMS: 1,2-Benzenedicarboxaldehyde; 2-Formylbenzaldehyde;1,2-Benzenedialdehyde; 1,2-Phthalic Dicarboxyaldehyde; OPA; PA; Phtalaldehydes (French);
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE: Light yellow crystalline powder
MELTING POINT: 56 C
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER
Soluble
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS
Health: 2 ; Flammability: 1 ; Reactivity: 0
REFRACTIVE INDEX
FLASH POINT
110 C
STABILITY: Stable under ordinary conditions
APPLICATIONS
Phthalaldehyde is used as a disinfectant and as a tanning agent in leather industry. It is useful for the sterilization of endoscopic instruments, thermometers, rubber and plastic equipment which cannot be sterilized by heating system. It is also used as an intermediate in synthesis of pharmaceuticals, medicines, and other organic compounds.
SALES SPECIFICATION
APPEARANCE
Light yellow crystalline powder
PURITY: 99.0% min
INDIVIDUAL IMPURITY: 0.5% max
WATER: 0.5% max
HAZARD CLASS: 8
UN NO.: 1759
REMARKS: In chemical sterilant field, phthalaldehyde, compare with glutaraldehyde, is not irritant to the eyes and nasal passages but has excellent stability over a wide range of pH (3-9), which does not require exposure monitoring, and has a barely perceptible odor. But phthaldialdehyde stains proteins gray including unprotected skin. Thus, it must be handled with use of gloves, eye protection, fluid-resistant gowns when handling contaminated instruments, contaminated equipment, and chemicals.
YELLOW SOLID IN VARIOUS FORMS WITH CHARACTERISTIC ODOUR.
Synthesis and reactions
The compound was first described in 1887 when it was prepared from α,α,α’,α’-tetrachloro-ortho-xylene. A more modern synthesis is similar: the hydrolysis of the related tetrabromoxylene using potassium oxalate, followed by purification by steam distillation.
The reactivity of OPA is complicated by the fact that in water it forms both a mono- and dihydrate, C6H4(CHO)(CH(OH)2) and C6H4(CH(OH))2O, respectively. Its reactions with nucleophiles often involves the reaction of both carbonyl groups
Biochemistry
OPA is used in a very sensitive fluorescent reagent for assaying amines or sulfhydryls in solution, notably contained in proteins, peptides, and amino acids, by capillary electrophoresis and chromatography. OPA reacts specifically with primary amines above their isoelectric point Pi in presence of thiols. OPA reacts also with thiols in presence of an amine such as n-propylamine or 2-aminoethanol. The method is spectrometric (fluorescent emission at 436-475 nm (max 455 nm) with excitation at 330-390 nm (max. 340 nm)).
O-Phthalaldehyde (OPA) is a chemical reagent that forms fluorescent conjugation products with primary amines. It is used for the detection of many biogenic amines, peptides, and proteins in nanogram quantities in body fluids. O-Phthalaldehyde is approved by FDA for use in test systems to detect blood urea nitrogen (BUN) for the diagnosis and treatment of certain renal and metabolic diseases. OPA is also a known desinfectant and has been approved for high-level sterilization of heat-sensitive medical instruments and is increasingly being used as a replacement in the healthcare industry for glutaraldehyde. OPA has also been approved for use as an indoor antimicrobial pesticide; an intermediate for the synthesis of pharmaceuticals, medicines, and other organic compounds.
Disinfection
OPA is commonly used as a high-level disinfectant for medical instruments, commonly sold under the brand names of Cidex OPA or TD-8. Disinfection with OPA is indicated for semi-critical instruments that come into contact with mucous membranes or broken skin, such as specula, laryngeal mirrors, and internal ultrasound probes.
Poly(phthalaldehyde)
OPA can be polymerized. In the polymer, one of the oxygen atoms forms a bridge to the other non-ring carbon of the same phthalaldehyde unit, while the other bridges to a non-ring carbon of another phthalaldehyde unit. Poly(phthalaldehyde) is used in making a photoresist.
In winemaking
The Nitrogen by O-Phthaldialdehyde Assay (NOPA) is one of the methods used in winemaking to measure yeast assimilable nitrogen (or YAN) needed by wine yeast in order to successfully complete fermentation.
Isomeric phthalaldehydes
Related to phthalaldehyde are:
isophthalaldehyde (benzene-1,3-dicarbaldehyde; m.p. 87–88 °C, CAS# 626-19-7)
terephthalaldehyde (benzene-1,4-dicarbaldehyde; m.p. 114–116 °C, CAS# 623-27-8)
IUPAC name: Phthalaldehyde
Preferred IUPAC name: Benzene-1,2-dicarbaldehyde
Other names: Benzene-1,2-dicarboxaldehyde; o-Phthalaldehyde; o-Phthalic dicarboxaldehyde; Phthaldialdehyde
CAS Number: 643-79-8
CHEBI:70851
ChemSpider: 4642
ECHA InfoCard 100.010.367
Properties
Chemical formula: C8H6O2
Molar mass: 134.134 g·mol−1
Appearance:Yellow solid
Density:1.19 g/mL
Melting point: 55.5 to 56 °C (131.9 to 132.8 °F; 328.6 to 329.1 K)
Boiling point: 266.1 °C (511.0 °F; 539.2 K)
Solubility in water: Low
Hazards
Main hazards: Toxic, Irritant
R-phrases (outdated): R25 R34 R43 R50
S-phrases (outdated): S26 S36/37/39
o-Phthalaldehyde, vapor fraction
Phthalaldehyde.IUPAC names: 1,2-Benzenedicarboxaldehyde;o-Phthalaldehyde;o-Phthalaldehyde;Phthaldialdehyd;o-Phthalaldehyde;o-Phthaldialdehyde;643-79-8
Aldehyde, ortho-Phthalico Phthalaldehydeo Phthaldialdehydeo-Phthalaldehydeo-Phthaldialdehydeortho Phthalaldehydeortho Phthalic Aldehydeortho-Phthalaldehydeortho-Phthalic AldehydeOrthophthaldialdehyde
benzene-1,2-dicarbaldehyde
o-Phthalaldehyde [for HPLC Labeling]
o-Phthalaldehyde
Cas no: 643-79-8
PHTHALALDEHYDE;PHTHARAL; o-Phthaldialdehyde; Benzene-1,2-dicarboxaldehyde; 1,2-Benzenedicarboxaldehyde; Phthaldialdehyde; Phthalic aldehyde; Phthalic dialdehyde; ortho-Phthalaldehyde; Phthalyldicarboxaldehyde; o-Phthaldehyde; benzene-1,2-dicarbaldehyde; Phthalic dicarboxaldehyde; Phthalaldialdehyde;o-Phthalicdicarboxaldehyde; 1,2-Diformylbenzene; 2-PHTHALALDEHYDE
O-fitalaldehit;O-fitalaldehid;orto fitalaldehit;orto-
O-Phthalaldehyde; O-Phthaldialdehyde; PHTHALALDEHYDE; 643-79-8; Benzene-1,2-dicarboxaldehyde; 1,2-Benzenedicarboxaldehyde; Aldehyde, ortho-Phthalic; o Phthalaldehyde; o Phthaldialdehyde; o-Phthalaldehyde; o-Phthaldialdehyde; ortho Phthalaldehyde; ortho Phthalic Aldehyde; ortho-Phthalaldehyde; ortho-Phthalic Aldehyde; Orthophthaldialdehyde; o-Phthalaldehyde; o-Phthaldialdehyde; PHTHALALDEHYDE; 643-79-8; Benzene-1,2-dicarboxaldehyde; 1,2-Benzenedicarboxaldehyde; Phthaldialdehyde; Phthalic aldehyde; Phthalic dialdehyde; o-Phthaldehyde; Phthalyldicarboxaldehyde; ortho-Phthalaldehyde; Phthalic dicarboxaldehyde; Phthalaldialdehyde; benzene-1,2-dicarbaldehyde; 1,2-Diformylbenzene; o-Phthalicdicarboxaldehyde; 2-PHTHALALDEHYDE; o-Phthalic dicarboxaldehyde; orthoPhthalaldehyde; OPTA; 1,2-Phthalic dicarboxaldehyde; OPA; CHEBI:70851; 1,2-BENZENEDICARBALDEHYDE; Phthaldialdehyde Reagent;Phtalaldehydes; NSC 13394; UNII-4P8QP9768A; ZWLUXSQADUDCSB-UHFFFAOYSA-N; ortho-Phthalaldehyde; 1,2-BENZENEDICARBALDEHYDE; 1,2-Benzenedicarboxaldehyde; 1,2-Phthalic dicarboxaldehyde; 2-Phthalaldehyde; benzene-1,2-dicarbaldehyde; Benzene-1,2-dicarboxaldehyde;BENZENEDICARBOXALDEHYDE; Benzol-1,2-dicarbaldehyd; OPA; o-Phthalaldehyde; o-Phthaldehyde; o-Phthaldialdehyde; o-Phthalic aldehyde;p-Benzenedicarboxaldehyde; Phtalaldéhyde; Phthalaldehyd; Phthalaldehyde; Phthalic dialdehyde; 1,2-Diformylbenzene; 211-402-2; 2-Phthaldehyde; 2-Phthaldehyde; 2-Phthaldialdehyde; 6-oxocyclohexa-2,4-diene-1,2-dicarboxaldehyde hydrate; Benzene-1,2-dicarboxaldehyde; OPA; o-Phthalaldehyde; o-Phthalic dicarboxaldehyde; Benzene-1,2-dicarboxaldehyde; OPA; O-Phthalaldialdehyde;o-Phthalic dicarboxaldehyde; o-Phthalicdicarboxaldehyde; OPTA; P-6600; Phtalaldehydes; Phthalaldialdehyde; Phthaldialdehyde;PHTHALIC ALDEHYDE; Phthalic dicarboxaldehyde; Phthalyldicarboxaldehyde; Phtharal; Phtharal
O-PHTHALALDEHYDE
PHTHARAL
O-PHTHALDIALDEHYDE
1,2-BENZENEDICARBOXALDEHYDE
1,2-Phthalic dicarboxaldehyde
ortho Phthalaldehyde
o-Phthalic dicarboxaldehyde
1,2-BENZENEDICARBALDEHYDE
OPA
OPTA
Phtalaldehydes [French]
2-PHTHALDIALDEHYDE
EINECS 211-402-2
Phtalaldehydes
1,2-Phthalic dicarboxaldehyde, 98+%
CAS-643-79-8
Orthophthaldialdehyde
ortho-Phthalic Aldehyde
phthalaldehyd
o-Phthalaldehyd
o-phthal aldehyde
orthophthalaldehyde
Phtharal (JAN)
Disopa (TN)
2-PHTHALDEHYDE
Phthaldialdehyde Reagent
PubChem17402
ORTHO-PHTHALADEHYDE
phthalaldehyde;Phthalaldehyde
O-PHTHALIC DIALDEHYDE
2-Phthaldehyde, High purity
Benzene-1,2-dicarboxakdehyde
1,2-Benzenedialdehyde;Phthalaldehyde
FLUORALDEHYDE(TM) O-PHTHALALDEHYDE
Phthaldialdehyde Reagent, Solution Complete
Phthaldialdehyde Reagent, Solution Incomplete
Phthaldialdehyde, for fluorescence, >=99.0% (HPLC)
6-Oxomethylene-5-[(E)-hydroxymethylene]cyclohexa-1,3-diene
6-Oxomethylene-5-[(Z)-hydroxymethylene]cyclohexa-1,3-diene
Phthaldialdehyde, >=97% (HPLC), powder (may contain lumps)
Phthaldialdehyde, suitable for HPLC fluorimetric detection of amino acids, >=99% (HPLC), powder
ortho-Phthalaldehyde
1,2-Benzenedicarboxaldehyde [ACD/Index Name]
211-402-2 [EINECS]
4-07-00-02138 (Beilstein Handbook Reference) [Beilstein]
643-79-8 [RN]
Benzene-1,2-dicarbaldehyde [ACD/IUPAC Name]
Benzene-1,2-dicarboxaldehyde [ACD/IUPAC Name]
Benzol-1,2-dicarbaldehyd [German]
o-Phthalaldehyde
o-Phthaldialdehyde
Phtalaldéhyde [French] [ACD/IUPAC Name]
Phthalaldehyd [German] [ACD/IUPAC Name]
Phthalaldehyde [ACD/IUPAC Name]
Phthaldialdehyde
VHR BVH [WLN]
[643-79-8]
o-phthalaldehyde
o-phthaldialdehyde
o-phthalicdicarboxaldehyde
1,2-Diformylbenzene
4P8QP9768A
68234-47-9 [RN]
BR-44048
CHEBI 70851
D03470
Disopa
Disopa (TN)
MFCD00003335 [MDL number]
NCGC00166206-01
OPA
OPTA
P-6600
Phtalaldehydes [French]
Phthalic dicarboxaldehyde
Phthalyldicarboxaldehyde
Phtharal
Phtharal (JAN)
SBB008450
SS-7380
STR01056
TH6950000 [RTECS]
UNII-4P8QP9768A
オルトフタルアルデヒド [Japanese]
Description
Formule moléculaire brute : C8H6O2
Principaux synonymes
Noms français :
1,2-Benzene dicarbonal
1,2-BENZENEDICARBOXALDEHYDE
ALDEHYDE ORTHO-PHTALIQUE
o-Phtaldialdéhyde
O-PHTHALDEHYDE
ortho-Phtalaldéhyde
ortho-phthalaldehyde
ORTHOPHTHALDIALDEHYDE
PHTALALDEHYDE (ORTHO-)
PHTHALIC O-DICARBOXALDEHYDE
Noms anglais :
o-Phthalaldehyde
o-Phthalic aldehyde
Commentaires
L'ortho-phtalaldéhyde pur est rarement rencontré dans le milieu de travail. Lorsqu'il est utilisé comme désinfectant, il se présente sous forme de solution aqueuse dont la concentration est d'environ 0,55 %. Les solutions commerciales contiennent des additifs qui permettent d'en stabiliser le pH, tels que l'acide citrique et les phosphates, des agents de conservation et des colorants.
Utilisation et sources d'émission:
L'ortho-phtalaldéhyde est surtout utilisé comme désinfectant chimique à haute efficacité pour des instruments dentaires ou médicaux, comme les endoscopes. Il est souvent considéré comme une alternative plus sécuritaire au glutaraldéhyde.
Il est également employé en laboratoire, comme réactif pour les analyses fluorométriques d'amines primaires et de thiols.
